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Medicine Reaction, Breast Problems

Many prescription and nonprescription medicines can cause breast problems, such as breast tenderness or nipple discharge. A few examples are:

  • Some antidepressants.
  • Some blood pressure medicines.
  • Corticosteroids, such as prednisone.
  • Medicines that contain hormones, such as birth control pills, hormone therapy, and infertility medicines.
  • Migraine headache medicines, such as sumatriptan.

Cimetidine, such as Tagamet, may cause nipple discharge and breast enlargement in men.

Current as of: May 1, 2026

Author: WebMD Ignite Staff

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