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Medicine Reaction, Leg Problems

Some medicines can cause leg problems. A few examples are:

  • Birth control pills and estrogen. These can increase the risk of blood clots in the leg, which may cause pain or swelling.
  • Calcium channel blockers, which are used to treat high blood pressure. These can cause leg swelling.
  • Diuretics. These can cause leg cramps.
  • Fluoroquinolones. These can increase the risk for tendinitis or tendon rupture.

Current as of: May 1, 2026

Author: WebMD Ignite Staff

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